Nanoscience Seminar Series | M.G. Finn

Viruses as Molecular Building Blocks
Tuesday, May 10, 2005 - 2:50pm
1464 CIEMAS Auditorium

M.G. Finn
Scripps Research Insitute

A great many nonenveloped virus particles of icosahedral and rodlike structure are available in quantity from cultured cells and plants. These systems represent a diverse set of nanoscale building blocks, which can be harnessed to a degree proportional to our understanding of their structure and chemical reactivity. Three icosahedral examples – cowpea mosaic virus, Nudaurelia capensis ω virus, and hepatitis B coat protein – have been engineered chemically and genetically to bear functional units in precise arrays on their exterior and interior protein surfaces. A survey of the syntheses, properties, and applications of such particles will be presented.